MolNFT v1 · #89725 · protein
Human SUN2-KASH1 complex
4DXR · Sun domain-containing protein 2: “Human SUN2-KASH1 complex”. X-ray diffraction, 1 ligand (K), 1 pocket (best druggability 0.53). MolNFT v1 #89725 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4DXR
- Type
- protein
- Length
- 221 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sun domain-containing protein 2; Nesprin-1
- UniProt
- Q9UH99, Q8NF91
- Ligands
- K
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sun domain-containing protein 2 | protein | 196 | 15% helix, 41% strand | Q9UH99 |
| B | Nesprin-1 | protein | 25 | 12% helix, 16% strand | Q8NF91 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 74 | 0.53 | 0.85 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 767 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UH99
- Every structure of UniProt Q8NF91
- Elsewhere: RCSB PDB 4DXR · PDBe 4DXR · UniProt Q9UH99 · UniProt Q8NF91
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