MolNFT v1 · #89572 · protein

Crystal structure of F95M aminoglycoside-2''-phosphotransferase type iva in complex with adenosine

4DTA · APH(2'')-id: “Crystal structure of F95M aminoglycoside-2''-phosphotransferase type iva in complex with adenosine”. X-ray diffraction, 1 ligand (ADN), 8 pockets (best druggability 0.79). MolNFT v1 #89572 on GenesisL1: 3D structure…

PDB: 4DTA
Type: protein
Length: 596 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: APH(2'')-id
UniProt: O68183
Ligands: ADN
Pockets: 8 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	APH(2'')-id	protein	298	49% helix, 15% strand	O68183

Ligands and binding sites

ADN · Adenosine · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	489	0.79	0.86	68	empty
2	305	0.74	0.86	47	empty
3	176	0.67	0.86	31	ADN
4	149	0.66	0.87	28	ADN
5	243	0.52	0.76	28	empty

Interfaces

1 interface between chains.

A–B · 1173 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

4DTA · Crystal Structure of F95M Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O68183
Elsewhere: RCSB PDB 4DTA · PDBe 4DTA · UniProt O68183

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.