MolNFT v1 · #89402 · protein

Crystal structure of an amidohydrolase (COG3618) from burkholderia multivorans (target efi-500235) with bound zn, space group C2

4DO7 · Amidohydrolase 2: “Crystal structure of an amidohydrolase (COG3618) from burkholderia multivorans (target efi-500235) with bound…”. X-ray diffraction, 2 ligands (ZN, SO4), 3 pockets (best druggability 0.71). MolNFT v1 #89402 on…

PDB: 4DO7
Type: protein
Length: 568 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Amidohydrolase 2
UniProt: A9ANE4
Ligands: ZN, SO4
Pockets: 3 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Amidohydrolase 2	protein	284	51% helix, 14% strand	A9ANE4

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B
SO4 · Sulfate ion · ion · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	482	0.71	0.81	62	empty
2	180	0.58	0.81	26	empty
3	215	0.57	0.79	25	ZN

Interfaces

1 interface between chains.

A–B · 549 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

4DO7 · Crystal structure of an amidohydrolase (cog3618) from burkholderia multivorans (target… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9ANE4
Elsewhere: RCSB PDB 4DO7 · PDBe 4DO7 · UniProt A9ANE4

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