MolNFT v1 · #8915 · protein
Crystal structure of the bacterial cell-division inhibitor minc from T. maritima
1HF2 · Septum site-determining protein minc: “Crystal structure of the bacterial cell-division inhibitor minc from T. maritima”. X-ray diffraction, 8 pockets (best druggability 0.70). MolNFT v1 #8915 on GenesisL1: 3D structure, binding…
- PDB
- 1HF2
- Type
- protein
- Length
- 794 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Septum site-determining protein minc
- UniProt
- Q9X0D7
- Pockets
- 8 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 16% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Septum site-determining protein minc | protein | 196 | 19% helix, 41% strand | Q9X0D7 |
| B | Septum site-determining protein minc | protein | 206 | 16% helix, 44% strand | Q9X0D7 |
| C | Septum site-determining protein minc | protein | 202 | 17% helix, 44% strand | Q9X0D7 |
| D | Septum site-determining protein minc | protein | 190 | 13% helix, 42% strand | Q9X0D7 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 901 | 0.70 | 0.76 | 73 | empty |
| 2 | 163 | 0.66 | 0.86 | 22 | empty |
| 3 | 444 | 0.58 | 0.74 | 55 | empty |
| 4 | 123 | 0.53 | 0.82 | 23 | empty |
| 5 | 125 | 0.51 | 0.81 | 18 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1107 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 971 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 935 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 603 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1HF2 · Crystal structure of the bacterial cell-division inhibitor MinC from T. maritima · the same entry in another collection · chain D against D, TM-score 1.00
- Q9X0D7 · AlphaFold monomer V2.0 prediction for probable septum site- determining protein minc… · a predicted model of the same protein · chain D against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X0D7
- Elsewhere: RCSB PDB 1HF2 · PDBe 1HF2 · UniProt Q9X0D7
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