MolNFT v1 · #88841 · protein
Structure of human transthyretin in complex with tolcapone
4D7B: “Structure of human transthyretin in complex with tolcapone”. X-ray diffraction, 1 ligand (TCW). MolNFT v1 #88841 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4D7B
- Type
- protein
- Length
- 232 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transthyretin
- UniProt
- P02766
- Ligands
- TCW
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transthyretin | protein | 116 | 6% helix, 51% strand | P02766 |
Ligands and binding sites
- TCW · Tolcapone · ligand · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 923 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 4D7B · Structure of human transthyretin in complex with Tolcapone · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02766
- Elsewhere: RCSB PDB 4D7B · PDBe 4D7B · UniProt P02766
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.