MolNFT v1 · #88671 · protein
Crystal structure of the kinase domain of CIPK24/SOS2
4D28 · Cbl-interacting SERINE/THREONINE-protein kinase 24: “Crystal structure of the kinase domain of CIPK24/SOS2”. X-ray diffraction, 12 pockets (best druggability 0.71). MolNFT v1 #88671 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4D28
- Type
- protein
- Length
- 1,101 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cbl-interacting SERINE/THREONINE-protein kinase 24
- EC
- 2.7.11.1
- UniProt
- Q9LDI3
- Pockets
- 12 · best druggability 0.71
Structure
x-ray diffraction · 4 distinct chains · 38% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cbl-interacting SERINE/THREONINE-protein kinase 24 (EC 2.7.11.1) | protein | 274 | 38% helix, 14% strand | Q9LDI3 |
| B | Cbl-interacting SERINE/THREONINE-protein kinase 24 (EC 2.7.11.1) | protein | 277 | 38% helix, 15% strand | Q9LDI3 |
| C | Cbl-interacting SERINE/THREONINE-protein kinase 24 (EC 2.7.11.1) | protein | 279 | 38% helix, 14% strand | Q9LDI3 |
| D | Cbl-interacting SERINE/THREONINE-protein kinase 24 (EC 2.7.11.1) | protein | 271 | 39% helix, 12% strand | Q9LDI3 |
Pockets
12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 939 | 0.71 | 0.76 | 85 | empty |
| 2 | 537 | 0.70 | 0.79 | 53 | empty |
| 3 | 575 | 0.69 | 0.78 | 58 | empty |
| 4 | 495 | 0.68 | 0.79 | 61 | empty |
| 5 | 70 | 0.67 | 0.93 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–D · 1460 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1365 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 764 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4D28 · Crystal structure of the kinase domain of CIPK24/SOS2 · the same entry in another collection · chain C against C, TM-score 1.00
- Q9LDI3 · AlphaFold monomer V2.0 prediction for cbl-interacting SERINE/THREONINE-protein kinase 24… · a predicted model of the same protein · chain D against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9LDI3
- Elsewhere: RCSB PDB 4D28 · PDBe 4D28 · UniProt Q9LDI3
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