MolNFT v1 · #88578 · protein
Structure of the sodium proton antiporter panhap from pyrococcus abyssii at pH 4.
4CZ9 · NA+/H+ antiporter, putative: “Structure of the sodium proton antiporter panhap from pyrococcus abyssii at pH 4.”. X-ray diffraction, 1 ligand (OOC), 12 pockets (best druggability 0.85). MolNFT v1 #88578 on GenesisL1: 3D structure…
- PDB
- 4CZ9
- Type
- protein
- Length
- 839 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NA+/H+ antiporter, putative
- UniProt
- Q9UZ55
- Ligands
- OOC
- Pockets
- 12 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NA+/H+ antiporter, putative | protein | 419 | 82% helix, 0% strand | Q9UZ55 |
| B | NA+/H+ antiporter, putative | protein | 420 | 80% helix, 0% strand | Q9UZ55 |
Ligands and binding sites
- OOC · octyl 4-O-beta-D-allopyranosyl-1-thio-beta-D-altropyranoside · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 809 | 0.85 | 0.87 | 52 | empty |
| 2 | 281 | 0.70 | 0.84 | 31 | empty |
| 3 | 544 | 0.69 | 0.79 | 38 | empty |
| 4 | 564 | 0.66 | 0.76 | 48 | empty |
| 5 | 413 | 0.64 | 0.78 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 2024 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4CZ9 · Structure of the sodium proton antiporter PaNhaP from Pyrococcus abyssii at pH 4. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UZ55
- Elsewhere: RCSB PDB 4CZ9 · PDBe 4CZ9 · UniProt Q9UZ55
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