MolNFT v1 · #88513 · protein

Monomeric pseudorabies virus protease PUL26N at 2.5 a resolution

4CX8: “Monomeric pseudorabies virus protease PUL26N at 2.5 a resolution”. X-ray diffraction, 9 pockets (best druggability 0.68). MolNFT v1 #88513 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4CX8
Type: protein
Length: 418 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pseudorabies virus protease
EC: 3.4.21.97
UniProt: Q83417
Pockets: 9 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pseudorabies virus protease (EC 3.4.21.97)	protein	212	32% helix, 22% strand	Q83417
B	Pseudorabies virus protease (EC 3.4.21.97)	protein	206	34% helix, 25% strand	Q83417

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	332	0.68	0.82	44	empty
2	350	0.60	0.77	37	empty
3	196	0.57	0.80	26	empty
4	155	0.43	0.75	22	empty
5	77	0.37	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 730 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

4CX8 · Monomeric pseudorabies virus protease pUL26N at 2.5 A resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q83417
Elsewhere: RCSB PDB 4CX8 · PDBe 4CX8 · UniProt Q83417

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