MolNFT v1 · #88378 · protein
Tyrosine kinase as - a common ancestor of src and abl bound to gleevec
4CSV · Src-abl tyrosine kinase ancestor: “Tyrosine kinase as - a common ancestor of src and abl bound to gleevec”. X-ray diffraction, 1 ligand (STI), 1 pocket (best druggability 0.70). MolNFT v1 #88378 on GenesisL1: 3D structure, binding…
- PDB
- 4CSV
- Type
- protein
- Length
- 244 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Src-abl tyrosine kinase ancestor
- EC
- 2.7.10.2
- Ligands
- STI
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Src-abl tyrosine kinase ancestor (EC 2.7.10.2) | protein | 244 | 41% helix, 16% strand | — |
Ligands and binding sites
- STI · 4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 467 | 0.70 | 0.80 | 47 | STI |
Compared structures
- 4CSV · Tyrosine kinase AS - a common ancestor of Src and Abl bound to Gleevec · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4CSV · PDBe 4CSV
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.