MolNFT v1 · #88365 · protein
Structural insights into toscana virus RNA encapsidation
4CSG · Nucleoprotein: “Structural insights into toscana virus RNA encapsidation”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #88365 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4CSG
- Type
- protein
- Length
- 2,975 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoprotein
- UniProt
- P21701
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 6 distinct chains · 60% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoprotein | protein | 246 | 59% helix, 1% strand | P21701 |
| B, E, J | Nucleoprotein | protein | 248 | 61% helix, 2% strand | P21701 |
| C, F, I, L | Nucleoprotein | protein | 247 | 58% helix, 2% strand | P21701 |
| D, K | Nucleoprotein | protein | 249 | 61% helix, 2% strand | P21701 |
| G | Nucleoprotein | protein | 248 | 62% helix, 2% strand | P21701 |
| H | Nucleoprotein | protein | 251 | 60% helix, 2% strand | P21701 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1184 | 0.81 | 0.82 | 130 | empty |
| 2 | 847 | 0.80 | 0.83 | 86 | empty |
| 3 | 893 | 0.80 | 0.82 | 104 | empty |
| 4 | 1111 | 0.80 | 0.81 | 95 | empty |
| 5 | 1069 | 0.80 | 0.81 | 103 | empty |
Interfaces
24 interfaces between chains.
- G–H · 1939 Ų buried · 14 hydrogen bonds · protein-protein
- K–L · 1837 Ų buried · 10 hydrogen bonds · protein-protein
- D–E · 1771 Ų buried · 12 hydrogen bonds · protein-protein
- A–F · 1692 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 1681 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 4CSG · Structural insights into Toscana virus RNA encapsidation · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21701
- Elsewhere: RCSB PDB 4CSG · PDBe 4CSG · UniProt P21701
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