MolNFT v1 · #88354 · protein

Crystal structure of PCNA from litopenaeus vannamei

4CS5 · Proliferating cell nuclear antigen: “Crystal structure of PCNA from litopenaeus vannamei”. X-ray diffraction, 9 pockets (best druggability 0.45). MolNFT v1 #88354 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4CS5
Type: protein
Length: 763 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proliferating cell nuclear antigen
UniProt: G1E6N7
Pockets: 9 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proliferating cell nuclear antigen	protein	255	18% helix, 40% strand	G1E6N7
B, C	Proliferating cell nuclear antigen	protein	254	18% helix, 40% strand	G1E6N7

Pockets

9 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.45	0.79	18	empty
2	87	0.38	0.76	17	empty
3	93	0.38	0.76	19	empty
4	59	0.37	0.79	16	empty
5	66	0.37	0.78	15	empty

Interfaces

3 interfaces between chains.

A–C · 710 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 709 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 708 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4CS5 · Crystal Structure of PCNA from Litopenaeus vannamei · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G1E6N7
Elsewhere: RCSB PDB 4CS5 · PDBe 4CS5 · UniProt G1E6N7

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