MolNFT v1 · #88224 · protein

Crystal structure kynurenine formamidase from pseudomonas aeruginosa

4COB: “Crystal structure kynurenine formamidase from pseudomonas aeruginosa”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.69). MolNFT v1 #88224 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4COB
Type: protein
Length: 412 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kynurenine formamidase
EC: 3.5.1.9
UniProt: Q9I234
Ligands: ZN
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Kynurenine formamidase (EC 3.5.1.9)	protein	206	15% helix, 28% strand	Q9I234

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	338	0.69	0.83	49	ZN
2	310	0.68	0.83	50	empty
3	61	0.32	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 2434 Å² buried · 33 hydrogen bonds · protein-protein

Compared structures

4COB · Crystal structure kynurenine formamidase from Pseudomonas aeruginosa · the same entry in another collection · chain A against A, TM-score 1.00
Q9I234 · AlphaFold monomer V2.0 prediction for kynurenine formamidase (Q9I234) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9I234
Elsewhere: RCSB PDB 4COB · PDBe 4COB · UniProt Q9I234

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