MolNFT v1 · #88103 · protein
PIH1 N-terminal domain
4CKT · PIH1 domain-containing protein 1: “PIH1 N-terminal domain”. X-ray diffraction, 2 pockets (best druggability 0.57). MolNFT v1 #88103 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4CKT
- Type
- protein
- Length
- 275 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PIH1 domain-containing protein 1; Telomere length regulation protein TEL2 homolog
- UniProt
- Q9CQJ2, Q9DC40
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 4 distinct chains · 25% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PIH1 domain-containing protein 1 | protein | 127 | 28% helix, 31% strand | Q9CQJ2 |
| B | PIH1 domain-containing protein 1 | protein | 132 | 26% helix, 27% strand | Q9CQJ2 |
| C | Telomere length regulation protein TEL2 homolog | protein | 8 | 0% helix, 0% strand | Q9DC40 |
| D | Telomere length regulation protein TEL2 homolog | protein | 8 | 0% helix, 0% strand | Q9DC40 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.57 | 0.81 | 32 | empty |
| 2 | 125 | 0.53 | 0.81 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–C · 450 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 422 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 365 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered, phosphorylation).
Compared structures
- 4CKT · PIH1 N-terminal domain · the same entry in another collection · chain D against D, TM-score 1.00
- Q9CQJ2 · AlphaFold monomer V2.0 prediction for PIH1 domain-containing protein 1 (Q9CQJ2) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q9DC40 · AlphaFold monomer V2.0 prediction for telomere length regulation protein TEL2 homolog… · a predicted model of the same protein · chain C against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9CQJ2
- Every structure of UniProt Q9DC40
- Elsewhere: RCSB PDB 4CKT · PDBe 4CKT · UniProt Q9CQJ2 · UniProt Q9DC40
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