MolNFT v1 · #88055 · protein + DNA

Burrh DNA-binding protein from burkholderia rhizoxinica in complex with its target DNA

4CJA: “Burrh DNA-binding protein from burkholderia rhizoxinica in complex with its target DNA”. X-ray diffraction, 3 pockets (best druggability 0.85). MolNFT v1 #88055 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4CJA
Type: protein + DNA
Length: 799 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Burrh; 5'-D(*DTP*TP*AP*AP*GP*AP*GP*AP*AP*GP*CP*AP*AP*DP *TP*AP*CP*GP*TP*TP*AP*TP*AP)-3'…
Pockets: 3 · best druggability 0.85

Structure

x-ray diffraction · 3 distinct chains · 68% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Burrh	protein	753	68% helix, 0% strand	—
B	5'-D(DTPTPAPAPGPAPGPAPAPGPCPAPAPDP TPAPCPGPTPTPAPTP*AP)-3'	dna	23	—	—
C	5'-D(DTPAPTPAPAPCPGPTPAPTPTPTPGPCP TPTPCPTPCPTPTPAP*AP)-3'	dna	23	—	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1069	0.85	0.87	128	empty
2	162	0.37	0.72	20	empty
3	52	0.22	0.72	9	empty

Interfaces

3 interfaces between chains.

A–B · 2908 Å² buried · 33 hydrogen bonds · protein-nucleic
B–C · 1011 Å² buried · 86 hydrogen bonds · nucleic-nucleic
A–C · 875 Å² buried · 10 hydrogen bonds · protein-nucleic

Compared structures

4CJA · BurrH DNA-binding protein from Burkholderia rhizoxinica in complex with its target DNA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4CJA · PDBe 4CJA

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.