MolNFT v1 · #88033 · protein

Complex of a BCL-W BH3 mutant with a BH3 domain

4CIM · BCL-2-like protein 2: “Complex of a BCL-W BH3 mutant with a BH3 domain”. X-ray diffraction. MolNFT v1 #88033 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4CIM
Type: protein
Length: 333 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BCL-2-like protein 2
UniProt: Q92843

Structure

x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BCL-2-like protein 2	protein	146	70% helix, 0% strand	Q92843
B	BCL-2-like protein 2	protein	145	70% helix, 0% strand	Q92843
P, Q	BCL-2-like protein 2	protein	21	76% helix, 0% strand	Q92843

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 16 copies · chains A, P, B, Q

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

6 interfaces between chains.

B–Q · 952 Å² buried · 14 hydrogen bonds · protein-protein
A–P · 948 Å² buried · 19 hydrogen bonds · protein-protein
P–Q · 439 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 199 Å² buried · 2 hydrogen bonds · protein-protein
A–Q · 168 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4CIM · Complex of a Bcl-w BH3 mutant with a BH3 domain · the same entry in another collection · chain Q against Q, TM-score 1.00
Q92843 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 2 (Q92843) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92843
Elsewhere: RCSB PDB 4CIM · PDBe 4CIM · UniProt Q92843

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