MolNFT v1 · #88028 · protein
Structure of lnta-K180D-K181D from listeria monocytogenes
4CIH · Listeria nuclear targeted protein a: “Structure of lnta-K180D-K181D from listeria monocytogenes”. X-ray diffraction, 7 pockets (best druggability 0.69). MolNFT v1 #88028 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4CIH
- Type
- protein
- Length
- 585 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Listeria nuclear targeted protein a
- UniProt
- Q8Y9T5
- Pockets
- 7 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | Listeria nuclear targeted protein a | protein | 146 | 76% helix, 0% strand | Q8Y9T5 |
| C | Listeria nuclear targeted protein a | protein | 147 | 76% helix, 0% strand | Q8Y9T5 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 241 | 0.69 | 0.85 | 43 | empty |
| 2 | 276 | 0.65 | 0.82 | 44 | empty |
| 3 | 426 | 0.62 | 0.77 | 44 | empty |
| 4 | 351 | 0.59 | 0.76 | 52 | empty |
| 5 | 145 | 0.45 | 0.76 | 23 | empty |
Interfaces
6 interfaces between chains.
- A–B · 775 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 688 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 611 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 294 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 242 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 4CIH · Structure of LntA-K180D-K181D from Listeria monocytogenes · the same entry in another collection · chain A against A, TM-score 1.00
- Q8Y9T5 · AlphaFold monomer V2.0 prediction for listeria nuclear targeted protein a (Q8Y9T5) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8Y9T5
- Elsewhere: RCSB PDB 4CIH · PDBe 4CIH · UniProt Q8Y9T5
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