MolNFT v1 · #87988 · protein
Crystal structure of the N-terminal domain of the pa subunit of thogoto virus polymerase (form 2)
4CHC · Polymerase acidic protein: “Crystal structure of the N-terminal domain of the pa subunit of thogoto virus polymerase (form 2)”. X-ray diffraction, 11 pockets (best druggability 0.76). MolNFT v1 #87988 on GenesisL1: 3D structure…
- PDB
- 4CHC
- Type
- protein
- Length
- 914 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase acidic protein
- UniProt
- P27194
- Pockets
- 11 · best druggability 0.76
Structure
x-ray diffraction · 5 distinct chains · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase acidic protein | protein | 162 | 41% helix, 14% strand | P27194 |
| B | Polymerase acidic protein | protein | 146 | 42% helix, 16% strand | P27194 |
| C, E | Polymerase acidic protein | protein | 161 | 43% helix, 14% strand | P27194 |
| D | Polymerase acidic protein | protein | 141 | 45% helix, 15% strand | P27194 |
| F | Polymerase acidic protein | protein | 143 | 41% helix, 15% strand | P27194 |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1031 | 0.76 | 0.78 | 110 | empty |
| 2 | 315 | 0.62 | 0.79 | 39 | empty |
| 3 | 62 | 0.49 | 0.85 | 13 | empty |
| 4 | 67 | 0.49 | 0.85 | 14 | empty |
| 5 | 183 | 0.44 | 0.74 | 29 | empty |
Interfaces
8 interfaces between chains.
- C–D · 895 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 857 Ų buried · 7 hydrogen bonds · protein-protein
- E–F · 832 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 596 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 525 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 4CHC · Crystal structure of the N-terminal domain of the PA subunit of Thogoto virus polymerase… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27194
- Elsewhere: RCSB PDB 4CHC · PDBe 4CHC · UniProt P27194
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