MolNFT v1 · #87963 · protein

Leishmania major N-myristoyltransferase in complex with a piperidinylindole inhibitor

4CGN · Glycylpeptide N-tetradecanoyltransferase: “Leishmania major N-myristoyltransferase in complex with a piperidinylindole inhibitor”. X-ray diffraction, 3 ligands (7AH, MYA, MG), 2 pockets (best druggability 0.80). MolNFT v1 #87963 on…

PDB: 4CGN
Type: protein
Length: 411 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glycylpeptide N-tetradecanoyltransferase
EC: 2.3.1.97
UniProt: Q4Q5S8
Ligands: 7AH, MYA, MG
Pockets: 2 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97)	protein	411	33% helix, 28% strand	Q4Q5S8

Ligands and binding sites

7AH · 2-(4-fluorophenyl)-N-(3-piperidin-4-yl-1H-indol-5-yl)ethanamide · ligand · chains A
MYA · Tetradecanoyl-coa · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	998	0.80	0.81	94	MG, 7AH, MYA
2	127	0.42	0.76	25	empty

Compared structures

4CGN · Leishmania major N-myristoyltransferase in complex with a piperidinylindole inhibitor · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4Q5S8
Elsewhere: RCSB PDB 4CGN · PDBe 4CGN · UniProt Q4Q5S8

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