MolNFT v1 · #87893 · protein
Crystal structure of the first MIF4G domain of human nonsense mediated decay factor UPF2
4CEM · Regulator of nonsense transcripts 2: “Crystal structure of the first MIF4G domain of human nonsense mediated decay factor UPF2”. X-ray diffraction, 6 pockets (best druggability 0.76). MolNFT v1 #87893 on GenesisL1: 3D structure…
- PDB
- 4CEM
- Type
- protein
- Length
- 617 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulator of nonsense transcripts 2
- UniProt
- Q9HAU5
- Pockets
- 6 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Regulator of nonsense transcripts 2 | protein | 308 | 72% helix, 1% strand | Q9HAU5 |
| B | Regulator of nonsense transcripts 2 | protein | 309 | 73% helix, 1% strand | Q9HAU5 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 777 | 0.76 | 0.80 | 81 | empty |
| 2 | 172 | 0.62 | 0.84 | 25 | empty |
| 3 | 207 | 0.62 | 0.82 | 26 | empty |
| 4 | 136 | 0.52 | 0.80 | 15 | empty |
| 5 | 123 | 0.48 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 378 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 4CEM · Crystal structure of the first MIF4G domain of human nonsense mediated decay factor UPF2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HAU5 · AlphaFold monomer V2.0 prediction for regulator of nonsense transcripts 2 (Q9HAU5) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HAU5
- Elsewhere: RCSB PDB 4CEM · PDBe 4CEM · UniProt Q9HAU5
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