MolNFT v1 · #87860 · protein
Crystal structure of PQBP1 bound to spliceosomal U5-15KD
4CDO · Thioredoxin-like protein 4A, polyglutamine-binding protein: “Crystal structure of PQBP1 bound to spliceosomal U5-15KD”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #87860 on GenesisL1: 3D structure, binding…
- PDB
- 4CDO
- Type
- protein
- Length
- 299 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thioredoxin-like protein 4A, polyglutamine-binding protein
- UniProt
- P83876, O60828
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thioredoxin-like protein 4A, polyglutamine-binding protein | protein | 150 | 33% helix, 21% strand | P83876, O60828 |
| C | Thioredoxin-like protein 4A, polyglutamine-binding protein | protein | 149 | 33% helix, 21% strand | P83876, O60828 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.52 | 0.83 | 19 | empty |
| 2 | 80 | 0.34 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–C · 389 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4CDO · Crystal structure of PQBP1 bound to spliceosomal U5-15kD · the same entry in another collection · chain A against A, TM-score 1.00
- P83876 · AlphaFold monomer V2.0 prediction for thioredoxin-like protein 4A (P83876) · a predicted model of the same protein · chain C against A, TM-score 0.87
- O60828 · AlphaFold monomer V2.0 prediction for polyglutamine-binding protein 1 (O60828) · a predicted model of the same protein · chain C against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P83876
- Every structure of UniProt O60828
- Elsewhere: RCSB PDB 4CDO · PDBe 4CDO · UniProt P83876 · UniProt O60828
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