Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for the regulation of angiogenesis

Structure

x-ray diffraction · 1 distinct chain · 23% helix, 44% strand (DSSP).

Ligands and binding sites

• GSH · Glutathione · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
• BMA · beta-D-mannopyranose · sugar
• GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 1 covalent, 1 disulfide, 1 glycan (covalent ligand, disulfide, N-glycosylation).

Compared structures

• 4CCV · Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an… · the same entry in another collection · chain A against A, TM-score 1.00
• Q28640 · AlphaFold monomer V2.0 prediction for histidine-rich glycoprotein (Q28640) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q28640
• Elsewhere: RCSB PDB 4CCV · PDBe 4CCV · UniProt Q28640