MolNFT v1 · #87830 · protein

Dengue 1 cryo-EM reconstruction

4CCT · Dengue virus 1 E protein: “Dengue 1 cryo-EM reconstruction”. Electron microscopy, 2 pockets (best druggability 0.29). MolNFT v1 #87830 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4CCT
Type: protein
Length: 1,707 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dengue virus 1 E protein; Dengue virus 1 M protein
UniProt: G3F5K5
Pockets: 2 · best druggability 0.29

Structure

electron microscopy · 2 distinct chains · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Dengue virus 1 E protein	protein	495	0% helix, 0% strand	G3F5K5
D, E, F	Dengue virus 1 M protein	protein	74	0% helix, 0% strand	G3F5K5

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.29	0.73	19	empty
2	52	0.27	0.72	14	empty

Interfaces

9 interfaces between chains.

B–C · 286 Å² buried · 0 hydrogen bonds · protein-protein
B–E · 264 Å² buried · 0 hydrogen bonds · protein-protein
A–D · 256 Å² buried · 0 hydrogen bonds · protein-protein
C–F · 249 Å² buried · 0 hydrogen bonds · protein-protein
A–C · 129 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4CCT · Dengue 1 cryo-EM reconstruction · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G3F5K5
Elsewhere: RCSB PDB 4CCT · PDBe 4CCT · UniProt G3F5K5

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