MolNFT v1 · #87670 · protein
Zebrafish ZNRF3 ectodomain crystal form II
4C85 · E3 ubiquitin-protein ligase ZNRF3: “Zebrafish ZNRF3 ectodomain crystal form II”. X-ray diffraction, 5 pockets (best druggability 0.49). MolNFT v1 #87670 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4C85
- Type
- protein
- Length
- 281 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase ZNRF3
- EC
- 6.3.2.-
- UniProt
- A5WWA0
- Pockets
- 5 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase ZNRF3 (EC 6.3.2.-) | protein | 143 | 23% helix, 38% strand | A5WWA0 |
| B | E3 ubiquitin-protein ligase ZNRF3 (EC 6.3.2.-) | protein | 138 | 24% helix, 36% strand | A5WWA0 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 89 | 0.49 | 0.82 | 19 | empty |
| 2 | 144 | 0.44 | 0.76 | 23 | empty |
| 3 | 52 | 0.36 | 0.79 | 9 | empty |
| 4 | 77 | 0.35 | 0.76 | 19 | empty |
| 5 | 65 | 0.28 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 814 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A5WWA0
- Elsewhere: RCSB PDB 4C85 · PDBe 4C85 · UniProt A5WWA0
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