MolNFT v1 · #87669 · protein
Zebrafish ZNRF3 ectodomain crystal form I
4C84 · E3 ubiquitin-protein ligase ZNRF3: “Zebrafish ZNRF3 ectodomain crystal form I”. X-ray diffraction, 4 pockets (best druggability 0.63). MolNFT v1 #87669 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4C84
- Type
- protein
- Length
- 277 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase ZNRF3
- EC
- 6.3.2.-
- UniProt
- A5WWA0
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase ZNRF3 (EC 6.3.2.-) | protein | 143 | 24% helix, 36% strand | A5WWA0 |
| B | E3 ubiquitin-protein ligase ZNRF3 (EC 6.3.2.-) | protein | 134 | 20% helix, 40% strand | A5WWA0 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.63 | 0.94 | 21 | empty |
| 2 | 112 | 0.44 | 0.77 | 23 | empty |
| 3 | 84 | 0.34 | 0.75 | 19 | empty |
| 4 | 56 | 0.29 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 817 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A5WWA0
- Elsewhere: RCSB PDB 4C84 · PDBe 4C84 · UniProt A5WWA0
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