MolNFT v1 · #87588 · protein
Measles virus phosphoprotein tetramerization domain
4C5Q: “Measles virus phosphoprotein tetramerization domain”. X-ray diffraction, 3 pockets (best druggability 0.71). MolNFT v1 #87588 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4C5Q
- Type
- protein
- Length
- 420 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoprotein
- UniProt
- P35974
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 5 distinct chains · 90% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Phosphoprotein | protein | 56 | 86% helix, 0% strand | P35974 |
| B, F | Phosphoprotein | protein | 55 | 87% helix, 0% strand | P35974 |
| C | Phosphoprotein | protein | 49 | 94% helix, 0% strand | P35974 |
| D, H | Phosphoprotein | protein | 51 | 92% helix, 0% strand | P35974 |
| G | Phosphoprotein | protein | 47 | 94% helix, 0% strand | P35974 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.71 | 0.97 | 15 | empty |
| 2 | 394 | 0.62 | 0.77 | 42 | empty |
| 3 | 303 | 0.58 | 0.77 | 33 | empty |
Interfaces
17 interfaces between chains.
- A–B · 1298 Ų buried · 12 hydrogen bonds · protein-protein
- E–F · 1295 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 1241 Ų buried · 12 hydrogen bonds · protein-protein
- E–H · 1230 Ų buried · 12 hydrogen bonds · protein-protein
- G–H · 1156 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4C5Q · measles virus phosphoprotein tetramerization domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35974
- Elsewhere: RCSB PDB 4C5Q · PDBe 4C5Q · UniProt P35974
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