MolNFT v1 · #87472 · protein

Crystal structure of the protease CTPB(S309A) present in a resting state

4C2E · Carboxy-terminal processing protease ctpb: “Crystal structure of the protease CTPB(S309A) present in a resting state”. X-ray diffraction, 6 pockets (best druggability 0.72). MolNFT v1 #87472 on GenesisL1: 3D structure, binding sites…

PDB: 4C2E
Type: protein
Length: 870 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carboxy-terminal processing protease ctpb
EC: 3.4.21.102
UniProt: O35002
Pockets: 6 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Carboxy-terminal processing protease ctpb (EC 3.4.21.102)	protein	435	34% helix, 24% strand	O35002

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	644	0.72	0.79	55	empty
2	731	0.72	0.78	56	empty
3	601	0.70	0.78	81	empty
4	521	0.67	0.78	70	empty
5	61	0.36	0.79	14	empty

Interfaces

1 interface between chains.

A–B · 2847 Å² buried · 44 hydrogen bonds · protein-protein

Compared structures

4C2E · Crystal structure of the protease CtpB(S309A) present in a resting state · the same entry in another collection · chain A against A, TM-score 1.00
O35002 · AlphaFold monomer V2.0 prediction for carboxy-terminal processing protease ctpb (O35002) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O35002
Elsewhere: RCSB PDB 4C2E · PDBe 4C2E · UniProt O35002

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