MolNFT v1 · #8715 · protein

Domain-swapped dimer of a human pancreatic ribonuclease variant

1H8X · Ribonuclease 1: “Domain-swapped dimer of a human pancreatic ribonuclease variant”. X-ray diffraction, 1 pocket (best druggability 0.27). MolNFT v1 #8715 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1H8X
Type: protein
Length: 250 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease 1
EC: 3.1.27.5
UniProt: P07998
Pockets: 1 · best druggability 0.27

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ribonuclease 1 (EC 3.1.27.5)	protein	125	21% helix, 38% strand	P07998

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.27	0.73	19	empty

Interfaces

1 interface between chains.

A–B · 1872 Å² buried · 41 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

1H8X · Domain-swapped Dimer of a Human Pancreatic Ribonuclease Variant · the same entry in another collection · chain A against A, TM-score 1.00
P07998 · AlphaFold monomer V2.0 prediction for ribonuclease pancreatic (P07998) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07998
Elsewhere: RCSB PDB 1H8X · PDBe 1H8X · UniProt P07998

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