MolNFT v1 · #87138 · protein
Crystal structure of the yeast DHH1-EDC3 complex
4BRU · ATP-dependent RNA helicase DHH1: “Crystal structure of the yeast DHH1-EDC3 complex”. X-ray diffraction, 5 pockets (best druggability 0.65). MolNFT v1 #87138 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4BRU
- Type
- protein
- Length
- 404 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent RNA helicase DHH1; Enhancer of mRNA-decapping protein 3
- EC
- 3.6.4.13
- UniProt
- P39517, P39998
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent RNA helicase DHH1 (EC 3.6.4.13) | protein | 375 | 40% helix, 17% strand | P39517 |
| B | Enhancer of mRNA-decapping protein 3 | protein | 29 | 28% helix, 0% strand | P39998 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 97 | 0.65 | 0.90 | 21 | empty |
| 2 | 125 | 0.45 | 0.78 | 21 | empty |
| 3 | 91 | 0.43 | 0.79 | 21 | empty |
| 4 | 90 | 0.36 | 0.75 | 18 | empty |
| 5 | 58 | 0.27 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1149 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 4BRU · Crystal structure of the yeast Dhh1-Edc3 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P39517 · AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase DHH1 (P39517) · a predicted model of the same protein · chain A against A, TM-score 0.59
- P39998 · AlphaFold monomer V2.0 prediction for enhancer of mRNA-decapping protein 3 (P39998) · a predicted model of the same protein · chain B against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P39517
- Every structure of UniProt P39998
- Elsewhere: RCSB PDB 4BRU · PDBe 4BRU · UniProt P39517 · UniProt P39998
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