MolNFT v1 · #87064 · protein

Structure and substrate induced conformational changes of the secondary citrate-sodium symporter cits revealed by electron crystallography

4BPQ · CITRATE\:SODIUM symporter: “Structure and substrate induced conformational changes of the secondary citrate-sodium symporter cits…”. Electron crystallography, 10 pockets (best druggability 0.67). MolNFT v1 #87064 on GenesisL1: 3D…

PDB: 4BPQ
Type: protein
Length: 622 residues
Chains: 2
Method: electron crystallography
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CITRATE\:SODIUM symporter
Pockets: 10 · best druggability 0.67

Structure

electron crystallography · 2 distinct chains · 90% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CITRATE\:SODIUM symporter	protein	304	90% helix, 0% strand	—
B	CITRATE\:SODIUM symporter	protein	318	90% helix, 0% strand	—

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	785	0.67	0.74	115	empty
2	660	0.63	0.74	96	empty
3	257	0.48	0.73	40	empty
4	212	0.46	0.74	40	empty
5	122	0.41	0.76	22	empty

Interfaces

1 interface between chains.

A–B · 765 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4BPQ · Structure and substrate induced conformational changes of the secondary citrate-sodium… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4BPQ · PDBe 4BPQ

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