MolNFT v1 · #87036 · protein
The structure and super-organization of acetylcholine receptor-rapsyn complexes class C
4BOO · Acetylcholine receptor subunit alpha: “The structure and super-organization of acetylcholine receptor-rapsyn complexes class C”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #87036 on GenesisL1: 3D structure…
- PDB
- 4BOO
- Type
- protein
- Length
- 1,849 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetylcholine receptor subunit alpha; Acetylcholine receptor beta subunit; Acetylcholine…
- UniProt
- P02711, Q6S3I0, Q6S3H8, Q6S3H9
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 4 distinct chains · 41% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Acetylcholine receptor subunit alpha | protein | 370 | 42% helix, 23% strand | P02711 |
| B | Acetylcholine receptor beta subunit | protein | 370 | 38% helix, 19% strand | Q6S3I0 |
| C | Acetylcholine receptor delta subunit | protein | 369 | 42% helix, 22% strand | Q6S3H8 |
| E | Acetylcholine receptor gamma subunit | protein | 370 | 42% helix, 18% strand | Q6S3H9 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1050 | 0.88 | 0.88 | 110 | empty |
| 2 | 457 | 0.83 | 0.90 | 48 | empty |
| 3 | 277 | 0.82 | 0.93 | 51 | empty |
| 4 | 181 | 0.82 | 0.96 | 43 | empty |
| 5 | 508 | 0.82 | 0.88 | 73 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1945 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 1837 Ų buried · 15 hydrogen bonds · protein-protein
- A–E · 1748 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1509 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 1393 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 4BOO · The structure and super-organization of acetylcholine receptor-rapsyn complexes class C · the same entry in another collection · chain B against B, TM-score 1.00
- P02711 · AlphaFold monomer V2.0 prediction for acetylcholine receptor subunit alpha (P02711) · a predicted model of the same protein · chain D against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02711
- Every structure of UniProt Q6S3I0
- Every structure of UniProt Q6S3H8
- Every structure of UniProt Q6S3H9
- Elsewhere: RCSB PDB 4BOO · PDBe 4BOO · UniProt P02711 · UniProt Q6S3I0 · UniProt Q6S3H8 · UniProt Q6S3H9
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