MolNFT v1 · #86963 · protein
Structure of the UBZ1AND2 tandem of the ubiquitin-binding adaptor protein TAX1BP1
4BMJ · TAX1-binding protein 1: “Structure of the UBZ1AND2 tandem of the ubiquitin-binding adaptor protein TAX1BP1”. X-ray diffraction, 2 ligands (ZN, CL), 15 pockets (best druggability 0.46). MolNFT v1 #86963 on GenesisL1: 3D structure…
- PDB
- 4BMJ
- Type
- protein
- Length
- 677 residues
- Chains
- 11
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TAX1-binding protein 1
- UniProt
- Q86VP1
- Ligands
- ZN, CL
- Pockets
- 15 · best druggability 0.46
Structure
x-ray diffraction · 11 distinct chains · 36% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TAX1-binding protein 1 | protein | 62 | 35% helix, 13% strand | Q86VP1 |
| B | TAX1-binding protein 1 | protein | 62 | 37% helix, 13% strand | Q86VP1 |
| C | TAX1-binding protein 1 | protein | 66 | 33% helix, 12% strand | Q86VP1 |
| D | TAX1-binding protein 1 | protein | 58 | 38% helix, 21% strand | Q86VP1 |
| E | TAX1-binding protein 1 | protein | 60 | 37% helix, 13% strand | Q86VP1 |
| F | TAX1-binding protein 1 | protein | 58 | 38% helix, 10% strand | Q86VP1 |
| G | TAX1-binding protein 1 | protein | 59 | 39% helix, 7% strand | Q86VP1 |
| H | TAX1-binding protein 1 | protein | 64 | 34% helix, 13% strand | Q86VP1 |
| I | TAX1-binding protein 1 | protein | 63 | 35% helix, 13% strand | Q86VP1 |
| J | TAX1-binding protein 1 | protein | 64 | 30% helix, 13% strand | Q86VP1 |
| K | TAX1-binding protein 1 | protein | 61 | 36% helix, 13% strand | Q86VP1 |
Ligands and binding sites
- ZN · Zinc ion · metal · 22 copies · chains A, B, C, D, E, F, G, H, I, J, K
- CL · Chloride ion · ion · 12 copies · chains A, B, C, D, E, F, G, H, I, J, K
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.46 | 0.76 | 27 | empty |
| 2 | 124 | 0.42 | 0.76 | 21 | empty |
| 3 | 107 | 0.38 | 0.75 | 18 | empty |
| 4 | 119 | 0.38 | 0.74 | 21 | empty |
| 5 | 86 | 0.35 | 0.75 | 18 | empty |
Interfaces
10 interfaces between chains.
- B–C · 844 Ų buried · 7 hydrogen bonds · protein-protein
- F–G · 827 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 822 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 790 Ų buried · 8 hydrogen bonds · protein-protein
- G–H · 788 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4BMJ · Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1 · the same entry in another collection · chain K against K, TM-score 1.00
- Q86VP1 · AlphaFold monomer V2.0 prediction for TAX1-binding protein 1 (Q86VP1) · a predicted model of the same protein · chain G against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86VP1
- Elsewhere: RCSB PDB 4BMJ · PDBe 4BMJ · UniProt Q86VP1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.