MolNFT v1 · #86916 · protein

Further structural insights into the binding of complement factor H by complement regulator acquiring surface protein 1, cspa (bbcrasp-1), of borrelia burgdorferi.

4BL4 · Complement regulator-acquiring surface protein 1 (crasp-1): “Further structural insights into the binding of complement factor H by complement regulator acquiring surface…”. X-ray diffraction, 3 pockets (best druggability 0.41).…

PDB: 4BL4
Type: protein
Length: 720 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Complement regulator-acquiring surface protein 1 (crasp-1)
UniProt: O50957
Pockets: 3 · best druggability 0.41

Structure

x-ray diffraction · 1 distinct chain · 82% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Complement regulator-acquiring surface protein 1 (crasp-1)	protein	180	82% helix, 0% strand	O50957

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	147	0.41	0.74	21	empty
2	120	0.39	0.74	17	empty
3	54	0.28	0.74	12	empty

Interfaces

2 interfaces between chains.

A–B · 2370 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 2369 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4BL4 · Further structural insights into the binding of complement factor H by complement… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O50957
Elsewhere: RCSB PDB 4BL4 · PDBe 4BL4 · UniProt O50957

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