MolNFT v1 · #86865 · protein
SFC1-SFC7 dimerization module
4BJJ · Transcription factor tau subunit SFC1: “SFC1-SFC7 dimerization module”. X-ray diffraction, 1 ligand (HG), 2 pockets (best druggability 0.44). MolNFT v1 #86865 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4BJJ
- Type
- protein
- Length
- 191 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription factor tau subunit SFC1; Transcription factor tau subunit SFC7
- UniProt
- O14229, A6X980
- Ligands
- HG
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription factor tau subunit SFC1 | protein | 106 | 24% helix, 33% strand | O14229 |
| B | Transcription factor tau subunit SFC7 | protein | 85 | 0% helix, 49% strand | A6X980 |
Ligands and binding sites
- HG · Mercury (II) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.44 | 0.82 | 21 | empty |
| 2 | 89 | 0.33 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1959 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 4BJJ · Sfc1-Sfc7 dimerization module · the same entry in another collection · chain A against A, TM-score 1.00
- A6X980 · AlphaFold monomer V2.0 prediction for transcription factor tau subunit SFC7 (A6X980) · a predicted model of the same protein · chain B against A, TM-score 0.91
- O14229 · AlphaFold monomer V2.0 prediction for transcription factor tau subunit SFC1 (O14229) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14229
- Every structure of UniProt A6X980
- Elsewhere: RCSB PDB 4BJJ · PDBe 4BJJ · UniProt O14229 · UniProt A6X980
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