MolNFT v1 · #86726 · protein
Crystal structure of E. COLI dihydrouridine synthase C (dusc) (selenomethionine derivative)
4BF9 · TRNA-dihydrouridine synthase C: “Crystal structure of E. COLI dihydrouridine synthase C (dusc) (selenomethionine derivative)”. X-ray diffraction, 1 ligand (FMN), 1 pocket (best druggability 0.63). MolNFT v1 #86726 on GenesisL1: 3D…
- PDB
- 4BF9
- Type
- protein
- Length
- 318 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA-dihydrouridine synthase C
- EC
- 1.3.1.-
- UniProt
- P33371
- Ligands
- FMN
- Pockets
- 1 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA-dihydrouridine synthase C (EC 1.3.1.-) | protein | 318 | 46% helix, 14% strand | P33371 |
Ligands and binding sites
- FMN · Flavin mononucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 139 | 0.63 | 0.86 | 29 | FMN |
Modifications
Observed in the structure: 7 modified (engineered).
Compared structures
- 4BF9 · Crystal structure of E. coli dihydrouridine synthase C (DusC) (selenomethionine… · the same entry in another collection · chain A against A, TM-score 1.00
- P33371 · AlphaFold monomer V2.0 prediction for tRNA-DIHYDROURIDINE(16) synthase (P33371) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33371
- Elsewhere: RCSB PDB 4BF9 · PDBe 4BF9 · UniProt P33371
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