MolNFT v1 · #86612 · protein
The crystal structure of sialidase vpi 5482 (btsa) from bacteroides thetaiotaomicron
4BBW · Sialidase (neuraminidase): “The crystal structure of sialidase vpi 5482 (btsa) from bacteroides thetaiotaomicron”. X-ray diffraction, 5 pockets (best druggability 0.69). MolNFT v1 #86612 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4BBW
- Type
- protein
- Length
- 520 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sialidase (neuraminidase)
- EC
- 3.2.1.18
- UniProt
- Q8AAK9
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sialidase (neuraminidase) (EC 3.2.1.18) | protein | 520 | 8% helix, 43% strand | Q8AAK9 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 334 | 0.69 | 0.82 | 26 | empty |
| 2 | 155 | 0.55 | 0.81 | 27 | empty |
| 3 | 175 | 0.50 | 0.77 | 26 | empty |
| 4 | 97 | 0.44 | 0.79 | 19 | empty |
| 5 | 52 | 0.25 | 0.73 | 16 | empty |
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
- 4BBW · The crystal structure of Sialidase VPI 5482 (BTSA) from Bacteroides thetaiotaomicron · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8AAK9
- Elsewhere: RCSB PDB 4BBW · PDBe 4BBW · UniProt Q8AAK9
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