MolNFT v1 · #8657 · protein

The crystal structure of diferric porcine serum transferrin

1H76 · Serotransferrin: “The crystal structure of diferric porcine serum transferrin”. X-ray diffraction, 3 ligands (NAG, FE, CO3), 9 pockets (best druggability 0.73). MolNFT v1 #8657 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1H76
Type: protein
Length: 677 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serotransferrin
UniProt: P09571
Ligands: NAG, FE, CO3
Pockets: 9 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serotransferrin	protein	677	36% helix, 19% strand	P09571

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
FE · Fe (III) ion · metal · 2 copies · chains A
CO3 · Carbonate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	165	0.73	0.91	36	empty
2	291	0.72	0.86	37	empty
3	278	0.56	0.77	34	empty
4	111	0.55	0.83	24	empty
5	150	0.52	0.79	19	empty

Modifications

Observed in the structure: 18 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

1H76 · The crystal structure of diferric porcine serum transferrin · the same entry in another collection · chain A against A, TM-score 1.00
P09571 · AlphaFold monomer V2.0 prediction for serotransferrin (P09571) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09571
Elsewhere: RCSB PDB 1H76 · PDBe 1H76 · UniProt P09571

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.