MolNFT v1 · #86443 · protein

The third member of the EIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety

4B6V · Eukaryotic translation initiation factor 4E type 3: “The third member of the EIF4E family represses gene expression via a novel mode of recognition of the…”. Solution nmr, 3 pockets (best druggability 0.48). MolNFT v1 #86443 on…

PDB: 4B6V
Type: protein
Length: 207 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic translation initiation factor 4E type 3
UniProt: Q9DBB5
Pockets: 3 · best druggability 0.48

Structure

solution nmr · 1 distinct chain · 28% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eukaryotic translation initiation factor 4E type 3	protein	207	28% helix, 25% strand	Q9DBB5

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	203	0.48	0.75	39	empty
2	74	0.33	0.75	12	empty
3	61	0.26	0.72	15	empty

Compared structures

4B6V · The third member of the eIF4E family represses gene expression via a novel mode of… · the same entry in another collection · chain A against A, TM-score 1.00
Q9DBB5 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E type 3… · a predicted model of the same protein · chain A against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9DBB5
Elsewhere: RCSB PDB 4B6V · PDBe 4B6V · UniProt Q9DBB5

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