MolNFT v1 · #86442 · protein

Solution structure of EIF4E3 in complex with M7GDP

4B6U · Eukaryotic translation initiation factor 4E type 3: “Solution structure of EIF4E3 in complex with M7GDP”. Solution nmr, 1 ligand (M7G), 1 pocket (best druggability 0.70). MolNFT v1 #86442 on GenesisL1: 3D structure, binding sites…

PDB: 4B6U
Type: protein
Length: 207 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic translation initiation factor 4E type 3
UniProt: Q9DBB5
Ligands: M7G
Pockets: 1 · best druggability 0.70

Structure

solution nmr · 1 distinct chain · 24% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eukaryotic translation initiation factor 4E type 3	protein	207	24% helix, 27% strand	Q9DBB5

Ligands and binding sites

M7G · 7N-methyl-8-hydroguanosine-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	389	0.70	0.81	44	M7G

Compared structures

4B6U · Solution structure of eIF4E3 in complex with m7GDP · the same entry in another collection · chain A against A, TM-score 1.00
Q9DBB5 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E type 3… · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9DBB5
Elsewhere: RCSB PDB 4B6U · PDBe 4B6U · UniProt Q9DBB5

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