MolNFT v1 · #86436 · protein

Trypansoma brucei tubulin binding cofactor B cap-gly domain

4B6M · Tubulin-specific chaperone, putative: “Trypansoma brucei tubulin binding cofactor B cap-gly domain”. X-ray diffraction, 2 pockets (best druggability 0.57). MolNFT v1 #86436 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4B6M
Type: protein
Length: 159 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tubulin-specific chaperone, putative
UniProt: D0A053
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tubulin-specific chaperone, putative	protein	80	4% helix, 41% strand	D0A053
B	Tubulin-specific chaperone, putative	protein	79	4% helix, 39% strand	D0A053

Ligands and binding sites

FMT · Formic acid · additive · 7 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	275	0.57	0.77	37	FMT
2	59	0.38	0.80	16	empty

Interfaces

1 interface between chains.

A–B · 397 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

4B6M · Trypansoma brucei tubulin binding cofactor B CAP-Gly domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D0A053
Elsewhere: RCSB PDB 4B6M · PDBe 4B6M · UniProt D0A053

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