MolNFT v1 · #86336 · protein

Family 1 6-phospho-beta-D glycosidase from streptococcus pyogenes

4B3K · Beta-glucosidase: “Family 1 6-phospho-beta-D glycosidase from streptococcus pyogenes”. X-ray diffraction, 20 pockets (best druggability 0.75). MolNFT v1 #86336 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4B3K
Type: protein
Length: 2,766 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-glucosidase
EC: 3.2.1.21, 3.2.1.86
UniProt: Q99YP9
Pockets: 20 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Beta-glucosidase (EC 3.2.1.21, 3.2.1.86)	protein	461	46% helix, 17% strand	Q99YP9

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	619	0.75	0.81	56	empty
2	568	0.75	0.82	54	empty
3	626	0.75	0.81	52	empty
4	616	0.75	0.81	58	empty
5	601	0.74	0.81	57	empty

Interfaces

11 interfaces between chains.

C–D · 758 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 752 Å² buried · 9 hydrogen bonds · protein-protein
E–F · 731 Å² buried · 8 hydrogen bonds · protein-protein
C–F · 215 Å² buried · 2 hydrogen bonds · protein-protein
A–E · 191 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4B3K · Family 1 6-phospho-beta-D glycosidase from Streptococcus pyogenes · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99YP9
Elsewhere: RCSB PDB 4B3K · PDBe 4B3K · UniProt Q99YP9

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.