MolNFT v1 · #86194 · protein
Crystal structure of the trypanosoma cruzi protein tyrosine phosphatase TCPTP1, a potential therapeutic target for chagas' disease
4AZ1 · Tyrosine specific protein phosphatase: “Crystal structure of the trypanosoma cruzi protein tyrosine phosphatase TCPTP1, a potential therapeutic…”. X-ray diffraction, 5 pockets (best druggability 0.73). MolNFT v1 #86194 on GenesisL1…
- PDB
- 4AZ1
- Type
- protein
- Length
- 586 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine specific protein phosphatase
- UniProt
- Q4E4C8
- Pockets
- 5 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine specific protein phosphatase | protein | 294 | 37% helix, 17% strand | Q4E4C8 |
| B | Tyrosine specific protein phosphatase | protein | 292 | 34% helix, 17% strand | Q4E4C8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 420 | 0.73 | 0.83 | 38 | empty |
| 2 | 359 | 0.63 | 0.78 | 40 | empty |
| 3 | 54 | 0.53 | 0.88 | 16 | EDO |
| 4 | 142 | 0.45 | 0.76 | 17 | empty |
| 5 | 100 | 0.40 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1031 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 4AZ1 · Crystal structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4E4C8
- Elsewhere: RCSB PDB 4AZ1 · PDBe 4AZ1 · UniProt Q4E4C8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.