MolNFT v1 · #8615 · protein
Cytochrome P450 14 alpha-sterol demethylase (CYP51) from mycobacterium tuberculosis in ferric low-spin state
1H5Z · Cytochrome P450 51: “Cytochrome P450 14 alpha-sterol demethylase (CYP51) from mycobacterium tuberculosis in ferric low-spin state”. X-ray diffraction, 2 ligands (HEM, FE2), 3 pockets (best druggability 0.75). MolNFT v1 #8615 on…
- PDB
- 1H5Z
- Type
- protein
- Length
- 434 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome P450 51
- EC
- 1.14.13.70
- UniProt
- P77901
- Ligands
- HEM, FE2
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytochrome P450 51 (EC 1.14.13.70) | protein | 434 | 51% helix, 12% strand | P77901 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 486 | 0.75 | 0.83 | 51 | HEM |
| 2 | 79 | 0.39 | 0.78 | 17 | empty |
| 3 | 63 | 0.33 | 0.76 | 18 | empty |
Compared structures
- 1H5Z · Cytochrome P450 14 alpha-sterol demethylase (CYP51) from mycobacterium tuberculosis in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P77901
- Elsewhere: RCSB PDB 1H5Z · PDBe 1H5Z · UniProt P77901
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