MolNFT v1 · #85972 · protein
Crystal structure of the NS6 protease from murine norovirus 1
4ASH: “Crystal structure of the NS6 protease from murine norovirus 1”. X-ray diffraction, 2 pockets (best druggability 0.63). MolNFT v1 #85972 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4ASH
- Type
- protein
- Length
- 353 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NS6 protease
- EC
- 3.4.22.66
- UniProt
- A7U693
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NS6 protease (EC 3.4.22.66) | protein | 177 | 5% helix, 48% strand | A7U693 |
| B | NS6 protease (EC 3.4.22.66) | protein | 176 | 7% helix, 48% strand | A7U693 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.63 | 0.86 | 30 | empty |
| 2 | 237 | 0.47 | 0.73 | 46 | empty |
Interfaces
1 interface between chains.
- A–B · 518 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4ASH · Crystal structure of the NS6 protease from murine norovirus 1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A7U693
- Elsewhere: RCSB PDB 4ASH · PDBe 4ASH · UniProt A7U693
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