MolNFT v1 · #85712 · protein
Crystal structure of the cytoplasmic actin capping protein CAP32_34 from dictyostelium discoideum
4AKR · F-actin-capping protein subunit alpha: “Crystal structure of the cytoplasmic actin capping protein CAP32_34 from dictyostelium discoideum”. X-ray diffraction, 8 pockets (best druggability 0.72). MolNFT v1 #85712 on GenesisL1: 3D…
- PDB
- 4AKR
- Type
- protein
- Length
- 1,028 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha; F-actin-capping protein subunit beta
- UniProt
- P13022, P13021
- Pockets
- 8 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 38% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-actin-capping protein subunit alpha | protein | 269 | 35% helix, 35% strand | P13022 |
| B | F-actin-capping protein subunit beta | protein | 245 | 40% helix, 37% strand | P13021 |
| C | F-actin-capping protein subunit alpha | protein | 271 | 38% helix, 35% strand | P13022 |
| D | F-actin-capping protein subunit beta | protein | 243 | 40% helix, 37% strand | P13021 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 669 | 0.72 | 0.79 | 84 | empty |
| 2 | 440 | 0.67 | 0.79 | 65 | empty |
| 3 | 163 | 0.56 | 0.81 | 23 | empty |
| 4 | 176 | 0.56 | 0.80 | 24 | empty |
| 5 | 336 | 0.54 | 0.74 | 34 | empty |
Interfaces
4 interfaces between chains.
- A–B · 3697 Ų buried · 53 hydrogen bonds · protein-protein
- C–D · 3693 Ų buried · 49 hydrogen bonds · protein-protein
- A–C · 258 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 22 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4AKR · Crystal Structure of the cytoplasmic actin capping protein Cap32_34 from Dictyostelium… · the same entry in another collection · chain D against D, TM-score 1.00
- P13021 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit beta (P13021) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P13022 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit alpha (P13022) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13022
- Every structure of UniProt P13021
- Elsewhere: RCSB PDB 4AKR · PDBe 4AKR · UniProt P13022 · UniProt P13021
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