MolNFT v1 · #85647 · protein

Crystallographic structure of an amyloidogenic variant, 3RC34Y, of the germinal line lambda 3

4AIX · Ig lambda chain V-IV region bau: “Crystallographic structure of an amyloidogenic variant, 3RC34Y, of the germinal line lambda 3”. X-ray diffraction, 2 pockets (best druggability 0.82). MolNFT v1 #85647 on GenesisL1: 3D structure…

PDB: 4AIX
Type: protein
Length: 424 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ig lambda chain V-IV region bau
Pockets: 2 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Ig lambda chain V-IV region bau	protein	106	6% helix, 50% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	966	0.82	0.84	124	empty
2	56	0.31	0.77	14	empty

Interfaces

6 interfaces between chains.

A–D · 568 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 539 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 248 Å² buried · 3 hydrogen bonds · protein-protein
C–D · 242 Å² buried · 2 hydrogen bonds · protein-protein
B–D · 163 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4AIX · Crystallographic structure of an amyloidogenic variant, 3rC34Y, of the germinal line… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4AIX · PDBe 4AIX

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