MolNFT v1 · #85477 · protein

HCV-J6 NS5B polymerase V405I mutant

4ADP · RNA-directed RNA polymerase: “HCV-J6 NS5B polymerase V405I mutant”. X-ray diffraction, 6 pockets (best druggability 0.79). MolNFT v1 #85477 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4ADP
Type: protein
Length: 564 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase
EC: 2.7.7.48
UniProt: Q9QF35
Pockets: 6 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed RNA polymerase (EC 2.7.7.48)	protein	564	49% helix, 15% strand	Q9QF35

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1081	0.79	0.81	89	empty
2	159	0.47	0.76	29	empty
3	106	0.42	0.77	19	empty
4	80	0.40	0.78	18	empty
5	88	0.36	0.76	23	empty

Compared structures

4ADP · HCV-J6 NS5B polymerase V405I mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9QF35
Elsewhere: RCSB PDB 4ADP · PDBe 4ADP · UniProt Q9QF35

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