MolNFT v1 · #85475 · protein
Fusidic acid resistance protein fusb
4ADN · FAR1: “Fusidic acid resistance protein fusb”. X-ray diffraction, 3 ligands (NA, ZN, CL), 4 pockets (best druggability 0.81). MolNFT v1 #85475 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4ADN
- Type
- protein
- Length
- 420 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FAR1
- UniProt
- Q8GNY5
- Ligands
- NA, ZN, CL
- Pockets
- 4 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | FAR1 | protein | 213 | 42% helix, 21% strand | Q8GNY5 |
| B | FAR1 | protein | 207 | 44% helix, 19% strand | Q8GNY5 |
Ligands and binding sites
- NA · Sodium ion · metal · 8 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- CL · Chloride ion · ion · chains A
- GOL · Glycerol · additive · 3 copies · chains A, B
- IMD · Imidazole · additive · 2 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1130 | 0.81 | 0.83 | 74 | NA, PEG |
| 2 | 166 | 0.52 | 0.78 | 17 | empty |
| 3 | 153 | 0.50 | 0.78 | 18 | empty |
| 4 | 145 | 0.41 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1155 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 4ADN · Fusidic acid resistance protein FusB · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8GNY5
- Elsewhere: RCSB PDB 4ADN · PDBe 4ADN · UniProt Q8GNY5
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