MolNFT v1 · #85326 · protein
Structure of the core asap complex
4A8X · RNA-binding protein with serine-rich domain 1: “Structure of the core asap complex”. X-ray diffraction, 3 pockets (best druggability 0.43). MolNFT v1 #85326 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4A8X
- Type
- protein
- Length
- 240 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-binding protein with serine-rich domain 1; Hook-like, isoform a; Histone deacetylase…
- UniProt
- Q15287, Q9VJ12, O55128
- Pockets
- 3 · best druggability 0.43
Structure
x-ray diffraction · 3 distinct chains · 22% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-binding protein with serine-rich domain 1 | protein | 88 | 23% helix, 36% strand | Q15287 |
| B | Hook-like, isoform a | protein | 27 | 33% helix, 19% strand | Q9VJ12 |
| C | Histone deacetylase complex subunit SAP18 | protein | 125 | 19% helix, 35% strand | O55128 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 115 | 0.43 | 0.77 | 22 | empty |
| 2 | 70 | 0.33 | 0.76 | 14 | empty |
| 3 | 74 | 0.31 | 0.73 | 17 | empty |
Interfaces
3 interfaces between chains.
- A–B · 628 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 626 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 406 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 4A8X · Structure of the core ASAP complex · the same entry in another collection · chain A against A, TM-score 1.00
- O55128 · AlphaFold monomer V2.0 prediction for histone deacetylase complex subunit SAP18 (O55128) · a predicted model of the same protein · chain C against A, TM-score 0.96
- Q15287 · AlphaFold monomer V2.0 prediction for RNA-binding protein with serine-rich domain 1… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15287
- Every structure of UniProt Q9VJ12
- Every structure of UniProt O55128
- Elsewhere: RCSB PDB 4A8X · PDBe 4A8X · UniProt Q15287 · UniProt Q9VJ12 · UniProt O55128
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