MolNFT v1 · #85223 · protein

Turnip yellow mosaic virus proteinase and escherichia COLI 30S ribosomal S15

4A5U · RNA replicase polyprotein: “Turnip yellow mosaic virus proteinase and escherichia COLI 30S ribosomal S15”. X-ray diffraction, 2 pockets (best druggability 0.36). MolNFT v1 #85223 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 4A5U
Type: protein
Length: 228 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA replicase polyprotein; 30S ribosomal protein S15
EC: 2.7.7.48
UniProt: P10358, E8Y371
Pockets: 2 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA replicase polyprotein (EC 2.7.7.48)	protein	148	31% helix, 24% strand	P10358
B	30S ribosomal protein S15	protein	80	75% helix, 0% strand	E8Y371

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.36	0.77	11	empty
2	60	0.33	0.77	14	empty

Interfaces

1 interface between chains.

A–B · 771 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

4A5U · Turnip yellow mosaic virus proteinase and Escherichia coli 30S ribosomal S15 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10358
Every structure of UniProt E8Y371
Elsewhere: RCSB PDB 4A5U · PDBe 4A5U · UniProt P10358 · UniProt E8Y371

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