MolNFT v1 · #85163 · protein
Yeast regulatory particle proteasome assembly chaperone HSM3 in complex with RPT1 C-terminal fragment
4A3V · DNA mismatch repair protein HSM3: “Yeast regulatory particle proteasome assembly chaperone HSM3 in complex with RPT1 C-terminal fragment”. X-ray diffraction, 6 pockets (best druggability 0.70). MolNFT v1 #85163 on GenesisL1: 3D…
- PDB
- 4A3V
- Type
- protein
- Length
- 1,079 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA mismatch repair protein HSM3; 26S protease regulatory subunit 7 homolog; Linker
- UniProt
- P38348, P33299
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 5 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA mismatch repair protein HSM3 | protein | 455 | 70% helix, 0% strand | P38348 |
| B | 26S protease regulatory subunit 7 homolog | protein | 79 | 58% helix, 3% strand | P33299 |
| C | DNA mismatch repair protein HSM3 | protein | 458 | 70% helix, 0% strand | P38348 |
| D | 26S protease regulatory subunit 7 homolog | protein | 77 | 60% helix, 3% strand | P33299 |
| E | Linker | protein | 10 | 0% helix, 0% strand | — |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1121 | 0.70 | 0.75 | 99 | empty |
| 2 | 600 | 0.68 | 0.77 | 54 | empty |
| 3 | 76 | 0.61 | 0.90 | 20 | empty |
| 4 | 88 | 0.58 | 0.87 | 22 | empty |
| 5 | 101 | 0.43 | 0.78 | 14 | empty |
Interfaces
7 interfaces between chains.
- A–B · 1130 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 1004 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 488 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 274 Ų buried · 4 hydrogen bonds · protein-protein
- B–E · 110 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4A3V · yeast regulatory particle proteasome assembly chaperone Hsm3 in complex with Rpt1… · the same entry in another collection · chain C against C, TM-score 1.00
- P33299 · AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 7 homolog (P33299) · a predicted model of the same protein · chain D against A, TM-score 0.96
- P38348 · AlphaFold monomer V2.0 prediction for DNA mismatch repair protein HSM3 (P38348) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38348
- Every structure of UniProt P33299
- Elsewhere: RCSB PDB 4A3V · PDBe 4A3V · UniProt P38348 · UniProt P33299
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